hrp0095p1-336 | Multisystem Endocrine Disorders | ESPE2022

Prevalence of Short Stature and Endocrinopathy in β-thalassemia Major Patients on Conventional Therapy in the Mediterranean and the Middle East countries

Soliman Ashraf , Soliman Nada , Elalaily Rania

Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). However, iron overload in parenchymal organs and endocrine glands still occurs in a good number of these patients.Objective: To evaluate the prevalence of iron-related complications (short stature, growth retardation, and growth hormone deficiency) in BTM.Methods: We performed an electronic search in PubM...

hrp0092p3-138 | GH and IGFs | ESPE2019

Factors Affecting Growth Response to Growth Hormone (GH) Therapy in Children with Short Stature and Normal GH and IGF-I Secretion and no Bone Age Delay

Elawwa Ahmed , Soliman Ashraf , Elalaily Rania

Background: There are inconsistencies in the results reported in a small number of previous studies into growth hormone (GH) treatment of short children with idiopathic short stature (ISS.Patients and Methods: Our study included 20 prepubertal (Tanner 1) or peri-pubertal (Tanner 2) children with short stature (HtSDS < -2) and/or HtSDS > 1SD below their mid parental height SD (MPHtSDS), slow Growth velocity( <...

hrp0082p3-d2-740 | Diabetes (3) | ESPE2014

Continuous Glucose Monitoring System in the Diagnosis of Early Glycemic Abnormalities in High-Risk Groups

Soliman Ashraf , Yassin Mohamed , Elawwa Ahmed , Elalaily Rania , De sanctis Vincenzo

Background: Continuous glucose monitoring (CGM) systems are an emerging technology that allows frequent glucose monitoring in real time.Objective and hypotheses: To assess the value of using CGM system (Medtronic) versus oral glucose tolerance (OGT) and HbA1c in the diagnosis of glycemic abnormalities (Prediabetes) in high-risk groups.Methods: We performed OGT and monitored glucose for 72 h using CGMS combined with four to five tim...

hrp0097p2-194 | Growth and Syndromes | ESPE2023

Impact of Undernutrition and Short Stature on The Quality of Life (QOL) in Children and adolescents with Beta thalassemia Major (BTM)

Soliman Ashraf , Ahmed Shayma , Soliman Nada , Elalaily Rania , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Itani Maya

Introduction: Quality of life (QoL), comprises physical, psychological, environmental, and social aspects, is an index designed to measure the burden of chronic diseases and evaluate the treatment outcome. Thalassemia major (BTM) is a chronic disease in children that harms children QoL by interrupting physical function, emotional function, social function, and school function. ObjectivesAim: This study aims to identify t...

hrp0097p2-87 | Multisystem Endocrine Disorders | ESPE2023

Undernutrition, abnormal body composition, and impaired linear growth in children and adolescents with Beta-Thalassemia Major: possible contributing factors

Soliman Ashraf , Ahmed Shayma , Alaaraj Nada , Elalaily Rania , Alyafei Fawzia , Hamed Noor , Soliman Nada

Introduction:Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). Malnutrition negatively affects their growth, efficacy of treatments, and quality of life.Objective: To evaluate the nutritional status and linear growth in 10 countries in the past 20 years.Methods: We performed an electronic search in PubMed, Google Scholar, and Web of Scie...